Maternal Overweight and Obesity during Pregnancy Are Associated with Neonatal, but Not Maternal, Hepcidin Concentrations.

ABSTRACT:

Background

Overweight or obesity among pregnant women may compromise maternal and neonatal iron status by upregulating hepcidin.

Objectives

This study determined the association of 1) maternal and neonatal iron status with maternal and neonatal hepcidin concentrations, and 2) maternal prepregnancy weight status with maternal and neonatal hepcidin concentrations.

Methods

We examined hematologic data from 405 pregnant women and their infants from the placebo treatment group of a pregnancy iron supplementation trial in rural China. We measured hepcidin, serum ferritin (SF), soluble transferrin receptor (sTfR), and high-sensitivity C-reactive protein in maternal blood samples at mid-pregnancy and in cord blood at delivery. We used regression analysis to examine the associ

SUBMITTER: Jones AD 

PROVIDER: S-EPMC8349130 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature