Lactobacillus plantarum Exhibits Antioxidant and Cytoprotective Activities in Porcine Intestinal Epithelial Cells Exposed to Hydrogen Peroxide.

ABSTRACT: Probiotics are widely used for protection against stress-induced intestinal dysfunction. Oxidative stress plays a critical role in gastrointestinal disorders. It is established that probiotics alleviate oxidative stress; however, the mechanism of action has not been elucidated. We developed an in vitro intestinal porcine epithelial cells (IPEC-J2) model of oxidative stress to explore the antioxidant effect and potential mode of action of Lactobacillus plantarum ZLP001. The IPEC-J2 cells were preincubated with and without L. plantarum ZLP001 for 3 h and then exposed to hydrogen peroxide (H₂O₂) for 4 h. Pretreatment with L. plantarum ZLP001 protected IPEC-J2 cells against H₂O₂-induced oxidative damage as indicated by cel

SUBMITTER: Wang J 

PROVIDER: S-EPMC8349292 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature