Computational repurposing of tamibarotene against triple mutant variant of SARS-CoV-2.

ABSTRACT: The outbreak of the triple mutant strain of severe acute respiratory syndrome coronavirus-2 (SARS-COV-2) was more virulent and pathogenic than its original strain. The viral triple mutant strain of SARS-COV-2 is extremely adaptive and increases penetrability into the host. The triple mutant viral strain was first reported in Brazil and South Africa and then communicated to different countries responsible for the second wave of the coronavirus disease (COVID-19) global pandemic with a high mortality rate. The reported genomic mutations are responsible for the alterations in the viral functional and structural proteins, causing the ineffectiveness of the existing antiviral therapy targeting these proteins. Thus, in current research, molecular docking simulation-based virtual screening of a l

SUBMITTER: Mujwar S 

PROVIDER: S-EPMC8349365 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature