Impact of Donor and Recipient Clinical Characteristics and Hepatic Histology on Steatosis/Fibrosis Following Liver Transplantation.

ABSTRACT:

Background

Deceased donor and recipient predictors of posttransplant steatosis/steatohepatitis and fibrosis are not well known. Our aim was to evaluate the prevalence and assess donor and recipient predictors of steatosis, steatohepatitis, and fibrosis in liver transplantation recipients.

Methods

Using the immune tolerance network A-WISH multicenter study (NCT00135694), donor and recipient demographic and clinical features were collected. Liver biopsies were taken from the donor liver at transplant, and from recipients per protocol and for-cause (ie, abnormal transaminases and to rule out rejection) and were interpreted by a central pathologist.

Results

One hundred eighty-three paired donor/recipients liver biopsies at the time of transplant and posttransplant follow-

SUBMITTER: Shaked O 

PROVIDER: S-EPMC8349377 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature