Preclinical and clinical biomarker studies of CT1812: A novel approach to Alzheimer's disease modification.

ABSTRACT:

Introduction

Amyloid beta (Aβ) oligomers are one of the most toxic structural forms of the Aβ protein and are hypothesized to cause synaptotoxicity and memory failure as they build up in Alzheimer's disease (AD) patients' brain tissue. We previously demonstrated that antagonists of the sigma-2 receptor complex effectively block Aβ oligomer toxicity. CT1812 is an orally bioavailable, brain penetrant small molecule antagonist of the sigma-2 receptor complex that appears safe and well tolerated in healthy elderly volunteers. We tested CT1812's effect on Aβ oligomer pathobiology in preclinical AD models and evaluated CT1812's impact on cerebrospinal fluid (CSF) protein biomarkers in mild to moderate AD patients in a clinical trial (ClinicalTrials.gov NCT02907567).

Methods

Experi

SUBMITTER: Izzo NJ 

PROVIDER: S-EPMC8349378 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature