Design of the Healthcare Worker Exposure Response and Outcomes (HERO) research platform.

ABSTRACT:

Background

The SARS CoV-2 virus has caused one of the deadliest pandemics in recent history, resulting in over 170 million deaths and global economic disruption. There remains an urgent need for clinical trials to test therapies for treatment and prevention.

Design

An online research platform was created to support a registry community of healthcare workers (HCWs) to understand their experiences and conduct clinical studies to address their concerns. The first study, HERO-HCQ, was a double-blind, multicenter, randomized, pragmatic trial to evaluate the superiority of hydroxychloroquine (HCQ) vs placebo for pre-exposure prophylaxis (PrEP) of COVID-19 clinical infection in HCWs. Secondary objectives were to assess the efficacy of HCQ in preventing viral shedding of COVID-19 am

SUBMITTER: Friedland A 

PROVIDER: S-EPMC8349387 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature