Statins reduce mortality in patients with COVID-19: an updated meta-analysis of 147 824 patients.

ABSTRACT:

Objectives

There is conflicting evidence about the efficacy of statin use in regard to clinical outcomes in patients with coronavirus disease 2019 (COVID-19). A systematic review and meta-analysis was performed to examine the effect of statin use on mortality in COVID-19 patients.

Methods

The electronic databases were searched, from inception to March 3, 2021. Unadjusted and adjusted effect estimates with their 95% confidence intervals (95% CI) were pooled using random-effects models.

Results

Twenty-five cohort studies involving 147 824 patients were included. The mean age of the patients ranged from 44.9 to 70.9 years; 57% of patients were male and 43% were female. The use of statins was not associated with mortality when applying the unadjusted risk ratio (uRR 1.16,

SUBMITTER: Diaz-Arocutipa C 

PROVIDER: S-EPMC8349445 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature