A tetrameric ACE2 protein broadly neutralizes SARS-CoV-2 spike variants of concern with elevated potency.
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ABSTRACT:
SUBMITTER: Leach A
PROVIDER: S-EPMC8349458 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Publications
A tetrameric ACE2 protein broadly neutralizes SARS-CoV-2 spike variants of concern with elevated potency.
Leach Adam A Ilca F Tudor FT Akbar Zulaikha Z Ferrari Mathieu M Bentley Emma M EM Mattiuzzo Giada G Onuoha Shimobi S Miller Ami A Ali Hanif H Rabbitts Terence H TH
Antiviral research 20210808
The SARS-CoV-2 receptor angiotensin converting enzyme 2 (ACE2) was previously engineered into a high affinity tetravalent format (ACE2-Fc-TD) that is a potential decoy protein in SARS-CoV-2 infection.We report that this protein shows greatly enhanced binding to SARS-CoV-2 spike proteins of the SARS-CoV-2 variants of concern B.1.1.7 (alpha variant, originally isolated in the United Kingdom) and B.1.351 (beta variant, originally isolated in South Africa) with picomolar compared with nanomolar Kd v ...[more]
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