Identification of prognostic immune-related gene signature associated with tumor microenvironment of colorectal cancer.

ABSTRACT:

Background

The tumor microenvironment (TME) has significantly correlation with tumor occurrence and prognosis. Our study aimed to identify the prognostic immune-related genes (IRGs)in the tumor microenvironment of colorectal cancer (CRC).

Methods

Transcriptome and clinical data of CRC cases were downloaded from TCGA and GEO databases. Stromal score, immune score, and tumor purity were calculated by the ESTIMATE algorithm. Based on the scores, we divided CRC patients from the TCGA database into low and high groups, and the differentially expressed genes (DEGs) were identified. Immune-related genes (IRGs) were selected by venn plots. To explore underlying pathways, protein-protein interaction (PPI) networks and functional enrichment analysis were used. After utilizing LASSO Co

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8349485 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature