Effect of dihydromyricetin on SARS-CoV-2 viral replication and pulmonary inflammation and fibrosis.

ABSTRACT:

Background

COVID-19 (Coronavirus Disease-2019) has spread widely around the world and impacted human health for millions. The lack of effective targeted drugs and vaccines forces scientific world to search for new effective antiviral therapeutic drugs. It has reported that flavonoids have potential inhibitory activity on SARS-CoV-2 M^pro and anti-inflammatory properties. Dihydromyricetin, as a flavonol, also has antiviral and anti-inflammatory potential. However, the inhibition of dihydromyricetin on SARS-CoV-2 M^pro and the protective effect of dihydromyricetin on pulmonary inflammation and fibrosis have not been proved and explained.

Purpose

The coronavirus main protease (M^pro) is essential for SARS-CoV-2 replication and to be recognized as a

SUBMITTER: Xiao T 

PROVIDER: S-EPMC8349562 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature