Intensity-modulated proton therapy for oropharyngeal cancer reduces rates of late xerostomia.

ABSTRACT:

Background and purpose

To determine rates of xerostomia after intensity-modulated radiotherapy (IMRT) or intensity-modulated proton therapy (IMPT) for oropharyngeal cancer (OPC) and identify dosimetric factors associated with xerostomia risk.

Materials and methods

Patients with OPC who received IMRT (n = 429) or IMPT (n = 103) from January 2011 through June 2015 at a single institution were studied retrospectively. Every 3 months after treatment, each patient completed an eight-item self-reported xerostomia-specific questionnaire (XQ; summary XQ score, 0-100). An XQ score of 50 was selected as the demarcation value for moderate-severe (XQs ≥ 50) and no-mild (XQs < 50) xerostomia. The mean doses and percent volumes of organs at risk receiving various doses (V5-V70) were extra

SUBMITTER: Cao J 

PROVIDER: S-EPMC8349568 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature