Partial depletion and repopulation of microglia have different effects in the acute MPTP mouse model of Parkinson's disease.

ABSTRACT:

Objectives

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive and selective degeneration of dopaminergic neurons. Microglial activation and neuroinflammation are associated with the pathogenesis of PD. However, the relationship between microglial activation and PD pathology remains to be explored.

Materials and methods

An acute regimen of MPTP was administered to adult C57BL/6J mice with normal, much reduced or repopulated microglial population. Damages of the dopaminergic system were comprehensively assessed. Inflammation-related factors were assessed by quantitative PCR and Multiplex immunoassay. Behavioural tests were carried out to evaluate the motor deficits in MPTP-challenged mice.

Results

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SUBMITTER: Li Q 

PROVIDER: S-EPMC8349650 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature