Gonadotropin response to insulin and lipid infusion reproduces the reprometabolic syndrome of obesity in eumenorrheic lean women: a randomized crossover trial.

ABSTRACT:

Objective

To study the reprometabolic syndrome in normal-weight, eumenorrheic women by infusing a combination of insulin and lipid. Women with obesity have been shown to have reduced gonadotropins and impaired luteinizing hormone (LH) and follicle-stimulating hormone (FSH) response to gonadotropin-releasing hormone (GnRH).

Design

Randomized crossover.

Setting

Academic medical center.

Participant(s)

Fifteen women, median age 32 (interquartile ranged [IQR] 26, 36) years and body mass index 21.9 (IQR 20.2, 22.9) kg/m² were recruited.

Intervention(s)

Early follicular phase, 6-hour infusions of insulin (20-40 mU/m² per minute) and lipid (Intralipid)-insulin/lipid infusion; or saline infusion (controls). The first 4 hours of each study as

SUBMITTER: Santoro N 

PROVIDER: S-EPMC8349763 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature