Conception by fertility treatment and offspring deoxyribonucleic acid methylation.

ABSTRACT:

Objective

To investigate whether deoxyribonucleic acid (DNA) methylation at birth and in childhood differ by conception using assisted reproductive technologies (ART) or ovulation induction compared with those in children conceived without fertility treatment.

Design

Upstate KIDS is a matched exposure cohort which oversampled on newborns conceived by treatment.

Setting

New York State (excluding New York City).

Patient(s)

This analysis included 855 newborns and 152 children at approximately 9 years of age.

Intervention(s)

None.

Main outcome measure(s)

DNA methylation levels were measured using the Illumina EPIC platform. Single CpG and regional analyses at imprinting genes were conducted.

Result(s)

Compared to no fertility treatment, ART was

SUBMITTER: Yeung EH 

PROVIDER: S-EPMC8349775 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature