Dataset Information

Testosterone-to-estradiol ratio and lung function in a prospective study of Puerto Rican youth.

ABSTRACT:

Background

Age- and sex-related differences in asthma may be due to changes in sex hormone levels.

Objective

To evaluate whether a change in free testosterone or free testosterone-to-estradiol ratio is associated with changes in lung function and eosinophils in the Puerto Rican youth.

Methods

We tested for the association between the change in sex hormone levels and change in lung function or change in eosinophils in a prospective study of 317 children (with and without asthma) followed up from ages 6 to 14 years to ages 10 to 20 years (146 females, 171 males) in San Juan, Puerto Rico. Serum levels of testosterone, estradiol, sex hormone-binding globulin, and progesterone were measured at 2 study visits, approximately 4.9 years apart. Using testosterone and sex hormone-binding globulin levels, we derived free testosterone and the free testosterone-to-estradiol ratio. Multivariable linear regression was used for the analysis of change in lung function and eosinophils, conducted separately by sex.

Results

In girls, each quartile increment in the free testosterone-to-estradiol ratio was associated with a 2.03% increment in percent predicted forced expiratory volume in 1 second (FEV₁)/forced vital capacity (FVC) between study visits. In males, each quartile increment in the free testosterone-to-estradiol ratio was associated with a 3.27% increment in percent predicted FEV₁ and a 1.81% increment in percent predicted FEV₁/FVC between study visits. In girls with asthma, an increased free testosterone-to-estradiol ratio was significantly associated with decreased eosinophils between visits (P=0.03).

Conclusion

In Puerto Rican youth, increased free testosterone-to-estradiol ratio over time was associated with an increased FEV₁/FVC in both sexes, and with an increased FEV₁ in males.

SUBMITTER: Han YY

PROVIDER: S-EPMC8349830 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

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Publications

Testosterone-to-estradiol ratio and lung function in a prospective study of Puerto Rican youth.

Han Yueh-Ying YY Forno Erick E Witchel Selma F SF Manni Michelle L ML Acosta-Pérez Edna E Canino Glorisa G Celedón Juan C JC

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20210420 2

<h4>Background</h4>Age- and sex-related differences in asthma may be due to changes in sex hormone levels.<h4>Objective</h4>To evaluate whether a change in free testosterone or free testosterone-to-estradiol ratio is associated with changes in lung function and eosinophils in the Puerto Rican youth.<h4>Methods</h4>We tested for the association between the change in sex hormone levels and change in lung function or change in eosinophils in a prospective study of 317 children (with and without ast ...[more]

PMID: 33892162

Similar Datasets

Project description:Changes in dietary patterns may partly explain the epidemic of asthma in industrialized countries. The objective of this study was to examine the relationship between dietary patterns and lung function and asthma exacerbations in Puerto Rican children. This is a case-control study of 678 Puerto Rican children (ages 6-14 years) in San Juan (Puerto Rico). All participants completed a respiratory health questionnaire and a 75-item food frequency questionnaire. Food items were aggregated into 7 groups: fruits, vegetables, grains, protein, dairy, fats, and sweets. Logistic regression was used to evaluate consumption frequency of each group and asthma. Based on the results, a dietary score was created [range from -2 (unhealthy diet: high consumption of dairy and sweets, low consumption of vegetables and grains) to 2 (healthy diet: high consumption of vegetables and grains and low consumption of dairy and sweet)]. Multivariable linear or logistic regression was used to assess the relationship between dietary score and lung function or asthma exacerbations. After adjustment for covariates, a healthier diet (each 1-point increment in dietary score) was associated with significantly higher %predicted forced expiratory volume in the first second (FEV1) and %predicted forced vital capacity (FVC) in control subjects. Dietary pattern alone was not associated with asthma exacerbations, but children with an unhealthy diet and vitamin D insufficiency (plasma 25(OH)D <30 ng/mL) had higher odds of ≥1 severe asthma exacerbation [odds ratio (OR) = 3.4, 95% confidence interval (CI) = 1.5-7.5] or ≥1 hospitalization due to asthma (OR = 3.9, 95% CI = 1.6-9.8, OR = 3.4, 95% CI = 1.5-7.5) than children who ate a healthy diet and were vitamin D sufficient. A healthy diet, with frequent consumption of vegetables and grains and low consumption of dairy products and sweets, was associated with higher lung function (as measured by FEV1 and FVC). Vitamin D insufficiency, together with an unhealthy diet, may have detrimental effects on asthma exacerbations in children.

Dataset Information

Testosterone-to-estradiol ratio and lung function in a prospective study of Puerto Rican youth.

Background

Objective

Methods

Results

Conclusion

Publications

Testosterone-to-estradiol ratio and lung function in a prospective study of Puerto Rican youth.

Similar Datasets

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