Testosterone-to-estradiol ratio and lung function in a prospective study of Puerto Rican youth.

ABSTRACT:

Background

Age- and sex-related differences in asthma may be due to changes in sex hormone levels.

Objective

To evaluate whether a change in free testosterone or free testosterone-to-estradiol ratio is associated with changes in lung function and eosinophils in the Puerto Rican youth.

Methods

We tested for the association between the change in sex hormone levels and change in lung function or change in eosinophils in a prospective study of 317 children (with and without asthma) followed up from ages 6 to 14 years to ages 10 to 20 years (146 females, 171 males) in San Juan, Puerto Rico. Serum levels of testosterone, estradiol, sex hormone-binding globulin, and progesterone were measured at 2 study visits, approximately 4.9 years apart. Using testosterone and sex hormon

SUBMITTER: Han YY 

PROVIDER: S-EPMC8349830 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature