Differential effects of estradiol on neural and emotional stress response in postmenopausal women with remitted Major Depressive Disorder.

ABSTRACT:

Background

Estrogen fluctuations throughout the lifespan may contribute to major depressive disorder (MDD) risk in women through effects on brain networks important in stress responding, and mood regulation. Although there is evidence to support ovarian hormone treatment for peri-menopausal depression, postmenopausal use has not been well examined. The objective of this study was to investigate whether estrogen modulation of the neural and emotional cognitive responses to stress differs between postmenopausal women with and without MDD history.

Methods

60 postmenopausal women completed an fMRI psychosocial stress task, after receiving no drug or 3 months of daily estradiol (E2). fMRI activity and subjective mood response were examined.

Results

In women without a histo

SUBMITTER: Albert KM 

PROVIDER: S-EPMC8349860 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature