Interfacing Biomaterials with Synthetic T Cell Immunity.

ABSTRACT: The clinical success of cancer immunotherapy is providing exciting opportunities for the development of new methods to detect and treat cancer more effectively. A new generation of biomaterials is being developed to interface with molecular and cellular features of immunity and ultimately shape or control anti-tumor responses. Recent advances that are supporting the advancement of engineered T cells are focused here. This class of cancer therapy has the potential to cure disease in subsets of patients, yet there remain challenges such as the need to improve response rates and safety while lowering costs to expand their use. To provide a focused overview, recent strategies in three areas of biomaterials research are highlighted: low-cost cell manufacturing to broaden patient access, noninva

SUBMITTER: Su FY 

PROVIDER: S-EPMC8349871 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature