Chronic unpredictable stress during adolescence protects against adult traumatic brain injury-induced affective and cognitive deficits.

ABSTRACT: Pre-clinical early-life stress paradigms model early adverse events in humans. However, the long-term behavioral consequences of early-life adversities after traumatic brain injury (TBI) in adults have not been examined. In addition, endocannabinoids may protect against TBI neuropathology. Hence, the current study assessed the effects of adverse stress during adolescence on emotional and cognitive performance in rats sustaining a TBI as adults, and how cannabinoid receptor 1 (CB1) activation impacts the outcome. On postnatal days (PND) 30-60, adolescent male rats were exposed to four weeks of chronic unpredictable stress (CUS), followed by four weeks of no stress (PND 60-90), or no stress at any time (Control), and then anesthetized and provided a cortical impact of moderate severity (2.8 

SUBMITTER: de la Tremblaye PB 

PROVIDER: S-EPMC8349874 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature