Refocusing the Immune Response to Selected Epitopes on a Zika Virus Protein Antigen by Nanopatterning.

ABSTRACT: Infections with Zika virus (ZIKV) are linked to the development of severe central nervous system disorders, but the need for a ZIKV vaccine remains unmet. Although the design of vaccines that elicit antibodies targeting domain III (DIII) of the ZIKV envelope (E) protein as an antigen is an attractive strategy, poorly neutralizing or cross-reactive antibodies that target the E protein may lead to antibody-dependent enhancement of disease. It is therefore decided to use the previously reported nanopatterning technique, which combines the site-specific incorporation of non-canonical amino acids with site-specific functionalization of the protein with polyethylene glycol (PEG), to shield selected epitopes on DIII. Two different nanopatterned DIII variants are designed and characterized and dem

SUBMITTER: Castro A 

PROVIDER: S-EPMC8349884 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature