Spike and wave discharges and fast ripples during posttraumatic epileptogenesis.

ABSTRACT:

Objective

The goal of the present study was to determine whether spike and wave discharges (SWDs) and SWDs with superimposed fast ripples (SWDFRs) could be biomarkers of posttraumatic epileptogenesis.

Methods

Fluid percussion injury was conducted on 13-14-week old male Sprague Dawley rats. Immediately after traumatic brain injury (TBI), they were implanted with microelectrodes in the neocortex, hippocampus, and striatum bilaterally. Age-matched sham rats with the same electrode implantation montage acted as controls. Wideband brain electrical activity was recorded intermittently from Day 1 of TBI, and continued from 2 to 21 weeks after TBI. SWD and SWDFR analysis was performed during the first 2 weeks to investigate whether the occurrence of this pattern predicted developmen

SUBMITTER: Kumar U 

PROVIDER: S-EPMC8349888 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature