The structural simplification of lysergic acid as a natural lead for synthesizing novel anti-Alzheimer agents.

ABSTRACT: Alzheimer's disease (AD) is a neurodegenerative disorder, projected to be the second leading cause of mortality by 2040. AD is characterized by a progressive impairment of memory leading to dementia and loss of ability to carry out daily functions. In addition to the deficiency of acetylcholine release in synapse, there are other mechanisms explaining the etiology of the disease. The most disputing ones are associated with the accumulation of damaged proteins β-amyloid (Aβ) and hyperphosphorylated tau outside and inside neurons, respectively. Lysergic acid derivatives have been shown to possess promising anti-Alzheimer effect. Moreover, lysergic acid structure encompasses the general structural requirements for acetylcholinesterase inhibition. In this study, sixteen analogues, derived from

SUBMITTER: Alzweiri M 

PROVIDER: S-EPMC8349890 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature