Blue poo: impact of gut transit time on the gut microbiome using a novel marker.

ABSTRACT:

Background and aims

Gut transit time is a key modulator of host-microbiome interactions, yet this is often overlooked, partly because reliable methods are typically expensive or burdensome. The aim of this single-arm, single-blinded intervention study is to assess (1) the relationship between gut transit time and the human gut microbiome, and (2) the utility of the 'blue dye' method as an inexpensive and scalable technique to measure transit time.

Methods

We assessed interactions between the taxonomic and functional potential profiles of the gut microbiome (profiled via shotgun metagenomic sequencing), gut transit time (measured via the blue dye method), cardiometabolic health and diet in 863 healthy individuals from the PREDICT 1 study.

Results

We found that gut micr

SUBMITTER: Asnicar F 

PROVIDER: S-EPMC8349893 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature