Characterization of Tbr2-expressing retinal ganglion cells.

ABSTRACT: The mammalian retina contains more than 40 retinal ganglion cell (RGC) subtypes based on their unique morphologies, functions, and molecular profiles. Among them, intrinsically photosensitive RGCs (ipRGCs) are the first specified RGC type emerging from a common retinal progenitor pool during development. Previous work has shown that T-box transcription factor T-brain 2 (Tbr2) is essential for the formation and maintenance of ipRGCs, and that Tbr2-expressing RGCs activate Opn4 expression upon native ipRGC ablation, suggesting that Tbr2⁺ RGCs contain a reservoir for ipRGCs. However, the identity of Tbr2⁺ RGCs has not been fully vetted. Here, using genetic sparse labeling and single cell recording, we showed that Tbr2-expressing retinal neurons include RGCs and a subset

SUBMITTER: Chen CK 

PROVIDER: S-EPMC8349894 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature