Impact of cancer screening on metastasis: A prostate cancer case study.

ABSTRACT:

Background

Trials of cancer screening present results in terms of deaths prevented, but metastasis is also a key endpoint that screening seeks to prevent. We developed a framework for projecting overall (de novo and progressive) metastases prevented in a screening trial using prostate cancer screening as a case study.

Methods

Mechanistic simulation model in which screening shifts a fraction of cases that would be metastatic at diagnosis to being non-metastatic. This shift increases the incidence of non-overdiagnosed, organ-confined cases. We use estimates of the risk of metastatic progression for these cases to project how many progress to metastasis after diagnosis and tally the projected de novo and progressive metastatic cases with and without screening. We use data on st

SUBMITTER: Lange J 

PROVIDER: S-EPMC8349931 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature