Atrial Fibrillation is Associated With Greater Risk of Dementia in Older Veterans.

ABSTRACT:

Objectives

To examine the association of atrial fibrillation (AF) with incident dementia in older veterans and the effect of anticoagulation on that association.

Methods

Around 407,871 veterans aged ≥55 years receiving care from US Veterans Health Administration between August 2003 and September 2015 were included in our retrospective study. AF and incident dementia were determined according to ICD-9-CM codes. Logistic regressions with veterans grouped into high-dimensional propensity scores deciles were used, and a mediation analysis was employed to examine the extent of cardio/cerebrovascular diseases that may also account for that association.

Results

AF was associated with greater dementia risk (odds ratio = 1.14; 95% confidence interval 1.07-1.22), partially medi

SUBMITTER: Rouch L 

PROVIDER: S-EPMC8349940 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature