Rapid screening of critically ill patients for low plasma vitamin C concentrations using a point-of-care oxidation-reduction potential measurement.

ABSTRACT:

Background

Hypovitaminosis C and vitamin C deficiency are common in critically ill patients and associated with organ dysfunction. Low vitamin C status often goes unnoticed because determination is challenging. The static oxidation reduction potential (sORP) reflects the amount of oxidative stress in the blood and is a potential suitable surrogate marker for vitamin C. sORP can be measured rapidly using the RedoxSYS system, a point-of-care device. This study aims to validate a model that estimates plasma vitamin C concentration and to determine the diagnostic accuracy of sORP to discriminate between decreased and higher plasma vitamin C concentrations.

Methods

Plasma vitamin C concentrations and sORP were measured in a mixed intensive care (IC) population. Our model estimati

SUBMITTER: Rozemeijer S 

PROVIDER: S-EPMC8349944 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature