The correlation between polymorphisms in the XPC gene and glioma susceptibility in a Chinese pediatric population.

ABSTRACT:

Background

A previous study revealed that single nucleotide polymorphisms (SNPs) in coding genes play a key role in tumorigenesis, genetic disorders, and drug resistance. Xeroderma pigmentosum group C (XPC) protein is a key DNA damage recognition factor that is required for maintaining the genomic stability. However, the correlation between XPC polymorphisms and glioma susceptibility is still unclear. Hence, this study aimed to investigate the correlation between XPC polymorphisms and pediatric glioma susceptibility.

Methods

A total of 399 participants (171 glioma patients and 228 controls) were enrolled to evaluate the correlation between XPC polymorphism and pediatric glioma susceptibility. The count data of two groups was analyzed by chi-square

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC8349950 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature