Efficacy evaluation and mechanical study of short- and long-term antithrombotic therapy for Kawasaki disease.

ABSTRACT:

Background

Antithrombotic therapy was commonly applied in treating Kawasaki disease (KD) children; however, the effects and mechanisms of different plans were not fully elucidated. In this study, we aimed to evaluate different antithrombotic drugs.

Methods

Eighty-two children diagnosed with KD in Hebei Children's Hospital from January 2017 to January 2020 were recruited. For cohort study, KD children were divided into a series of groups according to whether they were complicated with coronary artery lesions (CAL), drug therapy plan, and the presence of liver damage. The thromboelastogram (TEG) indexes [clotting time (R), clot formation time (K), clot formation angle (α), maximum amplitude of the clot (MA), arachidonic acid (AA), and adenosine diphosphate (ADP)] were employed

SUBMITTER: Hao J 

PROVIDER: S-EPMC8349964 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature