Neuropsychobiological Fingerprints of Chronic Fatigue in Sarcoidosis.

ABSTRACT:

Background

Chronic fatigue is a prominent symptom in many sarcoidosis patients, affecting quality of life and interfering with treatment. This study investigated neuropsychobiological mechanisms and markers of chronic fatigue in sarcoidosis.

Methods

Thirty patients with a histological diagnosis of sarcoidosis were included. The Multidimensional Fatigue Inventory was used to define patients with and without chronic fatigue. All patients were then characterised using several depression, quality of life questionnaires, and executive functioning. Cognitive functioning and underlying neural correlates were assessed using an n-back task measuring working memory and (sustained) attention during functional magnetic resonance imaging. Sarcoidosis disease activity was determined using

SUBMITTER: Kettenbach S 

PROVIDER: S-EPMC8350031 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature