Electrophysiological and Transcriptomic Features Reveal a Circular Taxonomy of Cortical Neurons.

ABSTRACT: The complete understanding of the mammalian brain requires exact knowledge of the function of each neuron subpopulation composing its parts. To achieve this goal, an exhaustive, precise, reproducible, and robust neuronal taxonomy should be defined. In this paper, a new circular taxonomy based on transcriptomic features and novel electrophysiological features is proposed. The approach is validated by analysing more than 1850 electrophysiological signals of different mouse visual cortex neurons proceeding from the Allen Cell Types database. The study is conducted on two different levels: neurons and their cell-type aggregation into Cre lines. At the neuronal level, electrophysiological features have been extracted with a promising model that has already proved its worth in neuronal dynamics.

SUBMITTER: Rodriguez-Collado A 

PROVIDER: S-EPMC8350032 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature