Aberrant modulation of brain activity underlies impaired working memory following traumatic brain injury.

ABSTRACT: Impaired working memory is a common and disabling consequence of traumatic brain injury (TBI) that is caused by aberrant brain processing. However, little is known about the extent to which deficits are perpetuated by specific working memory subprocesses. Using a combined functional magnetic resonance imaging (fMRI) and working memory paradigm, we tested the hypothesis that the pattern of brain activation subserving working memory following TBI would interact with both task demands and specific working memory subcomponents: encoding, maintenance, and retrieval. Forty-three patients with moderate-severe TBI, of whom 25 were in the acute phase of recovery (M = 2.16 months, SD = 1.48 months, range = 0.69 - 6.64 months) and 18 in the chronic phase of recovery (M = 23.44 months, SD = 6.76 month

SUBMITTER: Taing AS 

PROVIDER: S-EPMC8350067 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature