The prognostic role of the Transducin-like Enhancer of split protein family in lung adenocarcinoma.

ABSTRACT:

Background

Lung cancer claims more lives than any other cancer worldwide. Lung adenocarcinoma (LUAD) accounts for approximately 40% of all lung cancers. Members of the Transducin-like Enhancer of split (TLE) protein family repress transcription through multiple mechanisms; however, their prognostic value in LUAD is still unclear.

Methods

A dataset from The Cancer Genome Atlas was used to analyze the relationship between the expression of TLE family members and outcomes of LUAD. The expression of TLE family members in 59 normal and 513 tumor samples in the TCGA dataset was selected. For paired analysis, 57 normal and 57 tumor paired tissues were selected. Gene Ontology (GO) term and Reactome pathway enrichment analyses of the TLE family members were performed. Progression-fre

SUBMITTER: Ma Q 

PROVIDER: S-EPMC8350083 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature