P/FP ratio: incorporation of PEEP into the PaO₂/FiO₂ ratio for prognostication and classification of acute respiratory distress syndrome.

ABSTRACT:

Background

The current Berlin definition of acute respiratory distress syndrome (ARDS) uses the PaO₂/FiO₂ (P/F) ratio to classify severity. However, for the same P/F ratio, a patient on a higher positive end-expiratory pressure (PEEP) may have more severe lung injury than one on a lower PEEP.

Objectives

We designed a new formula, the P/FP ratio, incorporating PEEP into the P/F ratio and multiplying with a correction factor of 10 [(PaO₂*10)/(FiO₂*PEEP)], to evaluate if it better predicts hospital mortality compared to the P/F ratio post-intubation and to assess the resultant changes in severity classification of ARDS.

Methods

We categorized patients from a dataset of seven ARDS network trials using the thresholds of ≤ 100 (se

SUBMITTER: Palanidurai S 

PROVIDER: S-EPMC8350287 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature