Quantitative Analysis of Methylated Adenosine Modifications Revealed Increased Levels of N ⁶-Methyladenosine (m⁶A) and N ⁶,2'-O-Dimethyladenosine (m⁶Am) in Serum From Colorectal Cancer and Gastric Cancer Patients.

ABSTRACT: Colorectal cancer and gastric cancer are the most prevalent gastrointestinal malignancies worldwide, and early detection of these cancers is crucial to reduce their incidence and mortality. RNA methylation plays an important regulatory role in a variety of physiological activities, and it has drawn great attention in recent years. Methylated adenosine (A) modifications such as N ⁶-methyladenosine (m⁶A), N ¹-methyladenosine (m¹A), 2'-O-methyladenosine (Am), N ⁶,2'-O-dimethyladenosine (m⁶Am), and N ⁶,N ⁶-dimethyladenosine (m⁶ ₂A) are typical epigenetic markers of RNA, and they are closely correlated to various diseases including cancer

SUBMITTER: Hu Y 

PROVIDER: S-EPMC8350345 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature