Low-protein diet accelerates wound healing in mice post-acute injury.

ABSTRACT:

Background

Wound healing processes are influenced by macronutrient intake (protein, carbohydrate and fat). The most favourable diet for cutaneous wound healing is not known, although high-protein diets are currently favoured clinically. This experimental study investigates the optimal macronutrient balance for cutaneous wound healing using a mouse model and the Geometric Framework, a nutrient modelling method, capable of analyzing the individual and interactive effects of a wide spectrum of macronutrient intake.

Methods

Two adjacent and identical full-thickness skin excisions (1 cm²) were surgically created on the dorsal area of male C57BL/6 mice. Mice were then allocated to one of 12 high-energy diets that varied in protein, carbohydrate and fat content. In selec

SUBMITTER: Hew JJ 

PROVIDER: S-EPMC8350350 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature