Chaperonin Abundance Enhances Bacterial Fitness.
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ABSTRACT:
SUBMITTER: Kumar CMS
PROVIDER: S-EPMC8350394 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
Chaperonin Abundance Enhances Bacterial Fitness.
Kumar C M Santosh CMS Chugh Kritika K Dutta Anirban A Mahamkali Vishnuvardhan V Bose Tungadri T Mande Sharmila S SS Mande Shekhar C SC Lund Peter A PA
Frontiers in molecular biosciences 20210726
The ability of chaperonins to buffer mutations that affect protein folding pathways suggests that their abundance should be evolutionarily advantageous. Here, we investigate the effect of chaperonin overproduction on cellular fitness in <i>Escherichia coli</i>. We demonstrate that chaperonin abundance confers 1) an ability to tolerate higher temperatures, 2) improved cellular fitness, and 3) enhanced folding of metabolic enzymes, which is expected to lead to enhanced energy harvesting potential. ...[more]
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