The potential role of glycosaminoglycans in serum amyloid A fibril formation by in silico approaches.

ABSTRACT: Serum amyloid A (SAA) is actively involved in such pathological processes as atherosclerosis, rheumatoid arthritis, cancer and Alzheimer's disease by its aggregation. One of the factors that can attenuate its aggregation and so affects its physiological role is its interactions with glycosminoglycans (GAGs), linear anionic periodic polysaccharides. These molecules located in the extracellular matrix of the cell are highly variable in their chemical composition and sulfation patterns. Despite the available experimental evidence of SAA-GAG interactions, no mechanistic details at atomic level have been reported for these systems so far. In our work we aimed to apply diverse computational tools to characterize SAA-GAG complexes formation and to answer questions about their potential specificit

SUBMITTER: Maszota-Zieleniak M 

PROVIDER: S-EPMC8350538 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature