The effects of GelMA hydrogel on nerve repair and regeneration in mice with spinal cord injury.

ABSTRACT:

Background

To determine the effects of gelatin methacryloyl (GelMA) hydrogel on nerve repair and regeneration in mice with spinal cord injury (SCI).

Methods

A total of 30 ICR mice (6-8 weeks old) were randomly assigned into the control group, the model group, and the experimental group via the random digits table method. There were 10 mice in each group. All mice underwent a T8 laminectomy. For mice in the experimental group and the model group, after the T8 laminectomy, SCI models were constructed by clamping the mice spinal cord tissue for 1 minute using an aneurysm clip (25 g). Additionally, the SCI area of each mouse in the experimental group was locally injected with 0.05-0.7 mL GelMA hydrogel [10% (w/v)] and photocrosslinking was initiated under a blue light source wit

SUBMITTER: Zhang H 

PROVIDER: S-EPMC8350630 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature