Identification of significant immune-related genes for epilepsy via bioinformatics analysis.

ABSTRACT:

Background

Epilepsy is one of the most common neurological disorders, but its underlying mechanism has remained obscure, and the role of immune-related genes (IRGs) in epilepsy have not yet been investigated. Therefore, in this study, we explored the association between IRGs and epilepsy.

Methods

An IRG list was collected from the ImmPort database. The gene expression profiles of GSE143272 were collected from the Gene Expression Omnibus (GEO) database (https://www.ncbi.nlm.nih.gov/geo/). Differentially expressed genes (DEGs) between epilepsy and normal samples were analyzed, and the intersections between IRGs and DEGs were identified using the VennDiagram package, with the intersected genes subjected to further analysis. Enrichment function for intersected genes were perform

SUBMITTER: Luo X 

PROVIDER: S-EPMC8350633 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature