Assessment of liver injury using indocyanine green fluorescence imaging.

ABSTRACT:

Background

To investigate whether indocyanine green (ICG) fluorescence imaging can be used to evaluate chronic and acute liver injury induced by either a high-fat (HF) diet or carbon tetrachloride (CCl₄).

Methods

Sprague-Dawley (SD) rats were randomly divided into three groups: control group, HF diet-induced model group, and CCl₄-induced model group. The chronic and acute liver injury models were induced by a HF diet and intraperitoneal injection of CCl₄, respectively. After HF feeding, the liver index, levels of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) of the rats were determined. The livers were also collected to evaluate histopathology damage by hematoxylin and eosin (H&E) staining. After in vitro perfusion

SUBMITTER: Chen Y 

PROVIDER: S-EPMC8350635 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature