Identification of MAP3K15 as a potential prognostic biomarker and correlation with immune infiltrates in osteosarcoma.

ABSTRACT:

Background

Osteosarcoma (OS) is a type of primary malignant tumor, and increasing evidence shows the clinical benefits of immunotherapy in treating OS. However, the lack of comprehensive studies on the complex OS immune microenvironment hinders the application of immunotherapy. Thus, this study aimed to systematically explore the immune characteristics of OS and identify novel biomarkers for OS treatment.

Methods

We systematically studied the immune score and proportions of infiltrating immune cells in OS in the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) and Gene Expression Omnibus (GEO) databases using the ESTIMATE and CIBERSORT algorithms. Differential expression and functional analyses were used to identify dysregulated genes and explore

SUBMITTER: Chen Z 

PROVIDER: S-EPMC8350644 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature