Plasma proteomic profiling reveals biomarkers associated with aortic dilation in patients with bicuspid aortic valve.

ABSTRACT:

Background

Bicuspid aortic valve (BAV) is the most common congenital heart anomaly and is prone to cause complications, such as valvular stenosis and thoracic aortic dilation. There is currently no reliable way to predict the progression rate to thoracic aortic aneurysm. Here, we aimed to characterize the proteomic landscape in the plasma of stenotic BAV patients and provide potential biomarkers to predict progressive aortic dilation.

Methods

Plasma samples were obtained from 45 subjects (30 stenotic BAV patients and 15 healthy controls). All samples were properly prepared and analyzed using mass spectrometry (MS)-based label-free quantitative proteomics.

Results

A total of 748 plasma proteins had missingness <50%, and 193 (25.8%) were differentially expressed in the

SUBMITTER: Ma W 

PROVIDER: S-EPMC8350663 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature