The potential differential diagnosis value and clinical significance of CD35 expression in B-chronic lymphoproliferative disorders.

ABSTRACT:

Background

Flow cytometry for immunophenotyping is the main method for diagnosing chronic lymphocytic leukemia (CLL). Differential diagnosis between CLL and other B-chronic lymphoproliferative disorders (B-CLPDs) is sometimes difficult. This study aimed to investigate whether cluster of differentiation 35 (CD35) could be a useful marker for the differential diagnosis of CLL and other B-CLPDs.

Methods

The CD35 expression on lymphoma cells from 516 B-CLPD patients (347 CLL, 169 other B-CLPDs) was investigated through flow cytometry analysis. Serum C3 and C4 levels in B-CLPD patients were also evaluated.

Results

The results showed that the expression percentage and mean fluorescence intensity of CD35 were reduced in CLL cases compared with other B-CLPD patients. Furtherm

SUBMITTER: Shi Y 

PROVIDER: S-EPMC8350686 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature