Atorvastatin improves bone marrow endothelial progenitor cell function from patients with immune-related hemocytopenia.

ABSTRACT:

Background

Immune-related hemocytopenia (IRH) is a type of autoimmune disease that targets bone marrow hematopoietic cells. This study investigated the influence of atorvastatin on the functional aspects of bone marrow endothelial progenitor cells (BM EPCs) in IRH patients.

Methods

BM EPCs were isolated from 15 patients with IRH and 20 normal controls. The isolated BM EPCs were characterized by flow cytometry. Cell counting kit-8, flow cytometry, and Transwell migration assays were used to determine the proliferation, apoptosis, and migration of BM EPCs, respectively. Protein levels were determined by western blot assay.

Results

The BM EPCs isolated from IRH patients showed reduced proliferation, increased apoptosis, and attenuated migratory ability compared to those

SUBMITTER: Qian J 

PROVIDER: S-EPMC8350688 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature