Protective effects of fucoidan purified from Undaria pinnatifida against UV-irradiated skin photoaging.

ABSTRACT:

Background

Exposure to ultraviolet (UV) radiation (UVB and UVA) is the most well-known extrinsic factor that induces skin aging. Fucoidan has been shown to possess antiphotoaging effects against UV irradiation and can be used as an ingredient in the pharmaceutical industry. The present study evaluated the photoprotective effect of fucoidan purified from Undaria pinnatifida (UPF) on UV-induced skin photoaging and explored its potential molecular mechanism.

Methods

To evaluate the effect of UPF on UV-induced skin aging, HaCaT cells and HFF-1 cells were pretreated with or without UPF and then exposed to UVB and UVA radiation, respectively, and the levels of cellular senescence, reactive oxygen species (ROS) production and mitochondrial dysfunction were evaluated. The mit

SUBMITTER: Jing R 

PROVIDER: S-EPMC8350689 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature