Uncovering the pathophysiology of irritable bowel syndrome by exploring the gut-brain axis: a narrative review.

ABSTRACT:

Objective

To improve the pathophysiological understanding of irritable bowel syndrome (IBS) by exploring the gut-brain axis.

Background

Disorders of gut-brain interaction (DGBIs) are gastrointestinal (GI) disorders in which alterations in bowel functions occur. IBS, which is one of the most studied DGBIs, is linked with abdominal distress or pain without obvious structural or biochemical anomalies.

Methods

The etiology of IBS has not been clearly described but is known to be multifactorial, involving GI motility changes, post-infectious reactivity, visceral hypersensitivity, gut-brain interactions, microbiota dysbiosis, small intestinal bacterial overgrowth, food sensitivity, carbohydrate malabsorption, and intestinal inflammation.

Conclusions

One of the main f

SUBMITTER: Tang HY 

PROVIDER: S-EPMC8350700 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature