Administration of All-Trans Retinoic Acid to Pregnant Sows Alters Gut Bacterial Community of Neonatal Piglets With Different Hoxa1 Genotypes.

ABSTRACT: Administration of all-trans retinoic acid (ATRA) to pregnant sows improves developmental defects of Hoxa1^-/- fetal pigs, and this study aimed to explore the influence of maternal ATRA administration during pregnancy on gut microbiota of neonatal piglets. Samples of jejunal and ileal meconium of neonatal piglets before suckling were collected including 5 Hoxa1^-/- and 20 non-Hoxa1^-/- (Hoxa1^+/+ and Hoxa1^+/-) neonatal piglets from the control group and 5 Hoxa1^-/- and 7 non-Hoxa1^-/- neonatal piglets from the experimental group. Results indicated that Hoxa1 mutation shaped the bacterial composition of the jejunum and ileum of neonatal piglets and Hoxa1^-/- neonatal piglets had significantly higher diversity an

SUBMITTER: Zhou H 

PROVIDER: S-EPMC8350768 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature