Obesity and the Risk of Low Bicarbonate: A Cohort Study.

ABSTRACT:

Rationale & objective

Acid retention may occur in the absence of overt metabolic acidosis; thus it is important to identify populations at risk. Because obesity may alter renal acid-base handling, we sought to determine whether overweight and obesity are associated with increased risk for low serum bicarbonate levels, suggesting metabolic acidosis.

Study design

Retrospective cohort study.

Setting & participants

Adult patients (n = 96,147) visiting outpatient clinics in the Bronx, NY, between January 1, 2010, and December 31, 2015.

Predictor

Body mass index (BMI).

Outcome

Low serum bicarbonate level (≤23 mEq/L).

Analytical approach

Longitudinal analyses were conducted using mixed-effects models to examine associations of BMI with serum bicarbonate

SUBMITTER: Lambert DC 

PROVIDER: S-EPMC8350812 | biostudies-literature | 2021 Jul-Aug

REPOSITORIES: biostudies-literature