Pain and Obesity in Autosomal Dominant Polycystic Kidney Disease: A Post Hoc Analysis of the Halt Progression of Polycystic Kidney Disease (HALT-PKD) Studies.

ABSTRACT:

Rationale & objective

Pain is a frequent complication of autosomal dominant polycystic kidney disease (ADPKD) and includes back and abdominal pain. We hypothesized that in adults with early- and late-stage ADPKD, overweight and obesity are independently associated with greater self-reported back, abdominal, and radicular pain at baseline and that weight loss would be associated with decreased pain over a follow-up period.

Study design

Post hoc analysis of pooled data from 2 randomized trials.

Setting & participants

Participants in the HALT-PKD study A or B. 867 individuals were included in a cross-sectional analysis. 4,248 observations from 871 participants were included in a longitudinal analysis.

Predictor

Overweight and obesity (cross-sectional); annual chan

SUBMITTER: Nowak KL 

PROVIDER: S-EPMC8350824 | biostudies-literature | 2021 Jul-Aug

REPOSITORIES: biostudies-literature