Tau PET correlates with different Alzheimer's disease-related features compared to CSF and plasma p-tau biomarkers.

ABSTRACT: PET, CSF and plasma biomarkers of tau pathology may be differentially associated with Alzheimer's disease (AD)-related demographic, cognitive, genetic and neuroimaging markers. We examined 771 participants with normal cognition, mild cognitive impairment or dementia from BioFINDER-2 (n = 400) and ADNI (n = 371). All had tau-PET ([¹⁸ F]RO948 in BioFINDER-2, [¹⁸ F]flortaucipir in ADNI) and CSF p-tau181 biomarkers available. Plasma p-tau181 and plasma/CSF p-tau217 were available in BioFINDER-2 only. Concordance between PET, CSF and plasma tau biomarkers ranged between 66 and 95%. Across the whole group, ridge regression models showed that increased CSF and plasma p-tau181 and p-tau217 levels were independently of tau PET associated with higher age, and APOEɛ4-carriership

SUBMITTER: Ossenkoppele R 

PROVIDER: S-EPMC8350902 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature